| 1626 |
Redi postulated that living things do not arise from
spontaneous generation.
|
| 1655 |
Hooke described 'cells' in cork.
|
| 1674 |
Leeuwenhoek discovered protozoa. He saw bacteria
some 9 years later.
|
| 1833 |
Brown described the cell nucleus in cells of the
orchid.
|
| 1838 |
Schleiden and Schwann proposed cell theory.
|
| 1855 |
Virchow postulated that new cells come from
preexisting cells.
|
| 1857 |
Kolliker described
mitochondria.
|
| 1869 |
Miescher isolated DNA for the first time.
|
| 1879 |
Flemming described chromosome behavior during
mitosis.
|
| 1883 |
Germ cells are haploid, chromosome theory of
heredity.
|
| 1898 |
Golgi described the
golgi
apparatus.
|
| 1926 |
Svedberg developed the first analytical
ultracentrifuge.
|
| 1938 |
Behrens used
differential centrifugation to separate nuclei from
cytoplasm.
|
| 1939 |
Siemens produced the first commercial
transmission electron microscope.
|
| 1941 |
Coons used
fluorescent labeled antibodies to detect cellular
antigens.
|
| 1952 |
Gey and coworkers established a continuous human
cell line.
|
| 1953 |
Crick, Wilkins and Watson proposed structure of DNA
double-helix.
|
| 1955 |
Eagle systematically defined the nutritional needs
of animal cells in culture.
|
| 1957 |
Meselson, Stahl and Vinograd developed density
gradient centrifugation in cesium chloride solutions for
separating nucleic acids.
|
| 1965 |
Ham introduced a defined serum-free medium.
Cambridge Instruments produced the first commercial
scanning electron microscope.
|
| 1976 |
Sato and colleagues publish papers showing that
different cell lines require different mixtures of
hormones and growth factors in serum-free media.
|
| 1981 |
Transgenic mice and fruit flies are
produced. Mouse embryonic
stem cell line
established.
Reference: http://www.cell-biology.com/ |